Idiopathic Hypercalciuria

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Medullary nephrocalcinosis in idiopathic hypercalciuria

Idiopathic hypercalciuria is a metabolic abnormality characterized by excessive calcium excretion in the urine with normal serum calcium levels and is a common risk factor for formation of kidney stones and/or nephrocalcinosis. These patients benefit from a normal-calcium, reduced-animal protein, and low-salt diet, along with a thiazide diuretic.

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Bone disease and idiopathic hypercalciuria.

Observational and epidemiologic studies alike have shown that idiopathic hypercalciuric (IH) stone-forming patients typically show bone mineral density scores that are significantly lower than those observed for age- and sex-matched normal subjects or those for nonhypercalciuric stone-forming patients. Most of these studies have relied on changes in bone mineral density and have not explored th...

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Clinical manifestations of pediatric idiopathic hypercalciuria.

Idiopathic hypercalciuria (IH) is a common metabolic disorder in children with protean manifestations, many of which can mimic other common pediatric diseases. Reports in the medical literature describe children with IH presenting with a wide array of calculi and non-calculi related clinical symptoms such as hematuria, urinary tract infections (UTIs), urgency, urinary incontinence and recurrent...

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Treatment strategies for pediatric idiopathic hypercalciuria.

Idiopathic hypercalciuria (IH) is a common metabolic disorder in children and is associated with the development of renal calculi, nephrocalcinosis, hematuria and osteopenia. The effect of various dietary modifications and available pharmacologic therapies on reducing urinary calcium excretion and/or urinary supersaturation is discussed in this article. The importance of a multidisciplinary app...

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Epithelial Ca(2+) channel (ECAC1) in autosomal dominant idiopathic hypercalciuria.

BACKGROUND The epithelial Ca(2+) channel (ECaC) exhibits the defining properties for being the gatekeeper in 1,25-dihydroxyvitamin D(3)-regulated Ca(2+) (re)absorption. Its recently cloned human orthologue (ECaC1) could, therefore, represent a crucial molecule in human disorders related to Ca(2+)-wasting such as idiopathic hypercalciuria (IH). METHODS Fifty-seven members of nine families with...

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ژورنال

عنوان ژورنال: Proceedings of the Association of Clinical Biochemists

سال: 1961

ISSN: 0369-8564

DOI: 10.1177/036985646100100302